Biotechnology has made major progress
for creating substances over the recent past. Scientists all over the world use
various cell culture technologies on a daily basis. Cell culture is a method in
which cells are grown under artificial & controlled conditions. Also, the
techniques for the industrial production of biopharmaceuticals such as
antibodies, proteins, vaccines, etc. have shifted from the usual fermentation
technologies to the modern mammalian cell culture technologies. The global
market for cell culture protein surface coating is expected to grow at a
healthy CAGR over the estimated period (from 2014 to 2025). This growth is
attributed to the growing interests of scientists & biotechnology firms in
the stem cell R&D.
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Mammalian Cell Culture:
The gene therapy or tissue
engineering opens up new exciting fields. Bioreactors from small- to
large-scale have also been developed over the last few years for the
applications based on mammalian cell culture. The mammalian cell culture
technology is becoming a major field of
the modern biotechnology, particularly in the human health area. The term “mammalian
cell culture” is used for the cells of mammalians that are isolated from particular
tissues such as glands, liver, skin, and so on and further grown and recreated in
a man-made medium.
Fields of Products & Applications:
Among the products, rabies,
Foot-&-Mouth-Disease (FMD), and rubella for veterinary usage and hepatitis
B, viral vaccines against polio, mumps, and measles for human usage are the
important ones. The latest advance—for the large-scale viral vaccines production
with the cells dependent on anchorage—was the advent of microcarriers in the
late 60s. The latest targets for cell-based vaccines include the herpes simplex
virus, influenza, and Human Immunodeficiency Virus (HIV). Recent improvements include
DNA vaccines or genetically-designed vaccines
Monoclonal antibodies are now an important
tool for diagnostic uses, as well as for treatment. The significance of these antibodies
as therapeutic agents has increased in recent times, as the immunogenic mouse
antibodies were substituted by chimeric, human or humanized antibodies. The glycoprotein is another major group of mammalian
cell products.
The areas of application are cancer
diagnosis & treatment, Organ Transplantation (OKT3), leukemia, rheumatoid arthritis, multiple
sclerosis, and asthma. The latest recombinant methods focus on novel antibody
formats, for instance, bivalent antibodies or fragmented antibodies (FAb’s),
with a wide application range.
Market Insights:
The growing demands for
biopharmaceutical products (vaccines, antibodies, etc.) created using the help
of cell culture technology are expected to augment the cell culture protein
surface coating market growth. The key companies operating in the worldwide market
include Trevigen Inc.; Greiner Bio One
International GmbH; Merck KGaA; BioVision, Inc.; and PerkinElmer, Inc.
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